Preheat Your Oven: Start by preheating your oven to 375°F (190°C). This ensures that it's ready to rock and roll when your meatballs are all set to be baked to perfection.
In a large mixing bowl, combine the ground venison, ground beef, chopped onion, tomato paste, egg, garlic powder, oregano, salt, black pepper, and Worcestershire sauce. Get your hands in there and mix everything together until it's well combined.
Once your mixture is ready, it's time to roll it into meatballs. Take small portions of the mixture and roll them between your palms to form meatballs. Aim for meatballs that are about 1 to 1.5 inches in diameter. Place them on a baking sheet lined with parchment paper.
Preheat the cast iron skillet and add the olive oil. Lightly brown the meatballs on all sides to lock in the moisture and flavor. Be careful not to overcrowd your skillet.
Place the brown balls on a baking sheet on a piece of parchment. I prefer to cook them on a cooling rack. Pop the baking sheet into the preheated oven and bake for about 20-25 minutes, or until the meatballs are cooked through and golden brown on the outside.
Serve and Enjoy: Once your meatballs are ready, it's time to serve them up! You can spoon some marinara sauce over the meatballs and serve them with cooked pasta for a classic spaghetti and meatballs vibe.